Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
CRHCorticotropin releasing hormone. (198 aa)    
Predicted Functional Partners:
CRHR1
Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.
    
 0.996
CRHR2
Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.
    
 0.995
UCN
Urocortin.
  
 
0.983
UCN3
Urocortin 3.
    
 0.969
MC2R
Melanocortin 2 receptor.
     
 0.941
DRD1
Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.
     
 0.932
CRHBP
Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.
   
 0.922
VIPR2
Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family.
    
 0.917
TSHR
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
     
 0.915
GLP1R
Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.906
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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