STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101087880Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)    
Predicted Functional Partners:
BID
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
   
 
 0.907
BCL2
BCL2 apoptosis regulator.
   
 
 0.905
BCL2L1
BCL2 like 1.
     
 0.901
TMPRSS2
Transmembrane serine protease 2; Belongs to the peptidase S1 family.
 
   
 0.878
FURIN
Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.
  
 
 0.748
CTSB
Cathepsin B; Belongs to the peptidase C1 family.
  
0.697
BIRC3
Baculoviral IAP repeat containing 3.
   
 
 0.668
XIAP
X-linked inhibitor of apoptosis.
     
 0.657
BIRC5
Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]
     
 0.657
ACE2
Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]
      
 0.657
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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