Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NPHS2NPHS2 stomatin family member, podocin. (378 aa)    
Predicted Functional Partners:
CD2AP
CD2 associated protein.
   
 
 0.958
NPHS1
NPHS1 adhesion molecule, nephrin.
   
 0.938
WT1
WT1 transcription factor.
   
 0.914
TRPC6
Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family.
    
 
 0.899
PODXL
Podocalyxin like.
    
 0.797
KIRREL1
Kirre like nephrin family adhesion molecule 1.
    
 0.766
ALB
Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...]
      
 0.760
PLCE1
Phosphoinositide phospholipase C.
      
 0.753
SLC12A3
Solute carrier family 12 member 3.
   
 
 0.734
ANLN
Anillin actin binding protein.
    
 0.653
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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