Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DHRS7CDehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)    
Predicted Functional Partners:
DPP4
Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...]
      
 0.823
AKIP1
A-kinase interacting protein 1.
      
 0.762
SH3RF1
SH3 domain containing ring finger 1.
    
 0.698
FBXL16
F-box and leucine rich repeat protein 16.
    
 
 0.687
MCRIP1
MAPK regulated corepressor interacting protein 1.
    
 
 0.682
PRL
Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation.
      
 0.641
RETN
Uncharacterized protein.
      
 0.641
SAYSD1
SAYSVFN motif domain containing 1.
      
 0.636
TMEM98
Transmembrane protein 98.
      
 0.612
BATF2
Basic leucine zipper ATF-like transcription factor 2.
    
 
 0.603
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.