FOXS1 protein (Felis catus) - STRING interaction network

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[Homology]

Score

FOXS1

Forkhead box S1. (330 aa)

Predicted Functional Partners:

IRF4

0.783

BCL6

0.651

IL10

0.628

IL4

0.589

IRF1

0.557

MYLK2

0.533

SPI1

0.518

SPIB

0.518

STAT6

0.506

TRAF6

0.497

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	FOXS1	ENSFCAP00000006325	ENSFCAP00000001758	BCL6 transcription repressor.	Forkhead box S1.	0.651
BCL6	IL10	ENSFCAP00000006325	ENSFCAP00000012535	BCL6 transcription repressor.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.454
BCL6	IL4	ENSFCAP00000006325	ENSFCAP00000002290	BCL6 transcription repressor.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.850
BCL6	IRF4	ENSFCAP00000006325	ENSFCAP00000024564	BCL6 transcription repressor.	Interferon regulatory factor 4.	0.934
BCL6	SPIB	ENSFCAP00000006325	ENSFCAP00000031689	BCL6 transcription repressor.	ETS domain-containing protein.	0.402
BCL6	STAT6	ENSFCAP00000006325	ENSFCAP00000013518	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.471
FOXS1	BCL6	ENSFCAP00000001758	ENSFCAP00000006325	Forkhead box S1.	BCL6 transcription repressor.	0.651
FOXS1	IL10	ENSFCAP00000001758	ENSFCAP00000012535	Forkhead box S1.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.628
FOXS1	IL4	ENSFCAP00000001758	ENSFCAP00000002290	Forkhead box S1.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.589
FOXS1	IRF1	ENSFCAP00000001758	ENSFCAP00000012353	Forkhead box S1.	Interferon regulatory factor.	0.557
FOXS1	IRF4	ENSFCAP00000001758	ENSFCAP00000024564	Forkhead box S1.	Interferon regulatory factor 4.	0.783
FOXS1	MYLK2	ENSFCAP00000001758	ENSFCAP00000051751	Forkhead box S1.	Myosin light chain kinase 2.	0.533
FOXS1	SPI1	ENSFCAP00000001758	ENSFCAP00000002330	Forkhead box S1.	Spi-1 proto-oncogene.	0.518
FOXS1	SPIB	ENSFCAP00000001758	ENSFCAP00000031689	Forkhead box S1.	ETS domain-containing protein.	0.518
FOXS1	STAT6	ENSFCAP00000001758	ENSFCAP00000013518	Forkhead box S1.	Signal transducer and activator of transcription.	0.506
FOXS1	TRAF6	ENSFCAP00000001758	ENSFCAP00000047805	Forkhead box S1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.497
IL10	BCL6	ENSFCAP00000012535	ENSFCAP00000006325	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	BCL6 transcription repressor.	0.454
IL10	FOXS1	ENSFCAP00000012535	ENSFCAP00000001758	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Forkhead box S1.	0.628
IL10	IL4	ENSFCAP00000012535	ENSFCAP00000002290	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.932
IL10	IRF1	ENSFCAP00000012535	ENSFCAP00000012353	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interferon regulatory factor.	0.677