Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RNF152Ring finger protein 152. (203 aa)    
Predicted Functional Partners:
RRAGB
Ras related GTP binding B.
    
 0.886
RRAGA
Ras related GTP binding A.
    
 0.886
ZNF507
Zinc finger protein 507.
   
 0.765
INTS5
Integrator complex subunit 5.
      
 0.762
DNAJC11
DnaJ heat shock protein family (Hsp40) member C11.
      
 0.732
BNIP1
BCL2 interacting protein 1.
     
 0.687
PAQR9
Progestin and adipoQ receptor family member 9.
   
  
 0.607
GET4
Golgi to ER traffic protein 4.
      
 0.607
IRAK1
Interleukin 1 receptor associated kinase 1.
    
  0.590
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
 
 0.573
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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