Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PTGFRNProstaglandin F2 receptor inhibitor. (995 aa)    
Predicted Functional Partners:
CD9
CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, [...]
    
 
 0.971
CD81
Tetraspanin.
    
 
 0.969
TSPAN32
Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family.
    
 
 0.770
TSPAN2
Tetraspanin.
    
 
 0.681
LYPLA1
Lysophospholipase 1.
      
 0.612
CD151
Tetraspanin.
    
 
 0.603
TSPAN11
Tetraspanin.
    
 
 0.603
PHOSPHO1
Phosphoethanolamine/phosphocholine phosphatase.
      
 0.573
AS3MT
Arsenite methyltransferase.
      
 0.571
GDAP2
Ganglioside induced differentiation associated protein 2.
      
 0.569
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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