node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDX56 | SREBF1 | ENSFCAP00000026828 | ENSFCAP00000001834 | NPC1 like intracellular cholesterol transporter 1. | Sterol regulatory element binding transcription factor 1. | 0.818 |
DDX56 | SREBF2 | ENSFCAP00000026828 | ENSFCAP00000013258 | NPC1 like intracellular cholesterol transporter 1. | Sterol regulatory element binding transcription factor 2. | 0.803 |
FASN | PPARG | ENSFCAP00000010847 | ENSFCAP00000050722 | Fatty acid synthase. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.740 |
FASN | SCAP | ENSFCAP00000010847 | ENSFCAP00000014353 | Fatty acid synthase. | SREBF chaperone. | 0.530 |
FASN | SCD | ENSFCAP00000010847 | ENSFCAP00000025038 | Fatty acid synthase. | Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. | 0.907 |
FASN | SREBF1 | ENSFCAP00000010847 | ENSFCAP00000001834 | Fatty acid synthase. | Sterol regulatory element binding transcription factor 1. | 0.843 |
FASN | SREBF2 | ENSFCAP00000010847 | ENSFCAP00000013258 | Fatty acid synthase. | Sterol regulatory element binding transcription factor 2. | 0.647 |
KPNB1 | SREBF1 | ENSFCAP00000019089 | ENSFCAP00000001834 | Karyopherin subunit beta 1. | Sterol regulatory element binding transcription factor 1. | 0.895 |
KPNB1 | SREBF2 | ENSFCAP00000019089 | ENSFCAP00000013258 | Karyopherin subunit beta 1. | Sterol regulatory element binding transcription factor 2. | 0.947 |
MBTPS2 | SREBF1 | ENSFCAP00000035313 | ENSFCAP00000001834 | Membrane bound transcription factor peptidase, site 2. | Sterol regulatory element binding transcription factor 1. | 0.840 |
MBTPS2 | SREBF2 | ENSFCAP00000035313 | ENSFCAP00000013258 | Membrane bound transcription factor peptidase, site 2. | Sterol regulatory element binding transcription factor 2. | 0.854 |
NPC1 | SREBF1 | ENSFCAP00000030178 | ENSFCAP00000001834 | NPC intracellular cholesterol transporter 1. | Sterol regulatory element binding transcription factor 1. | 0.778 |
NPC1 | SREBF2 | ENSFCAP00000030178 | ENSFCAP00000013258 | NPC intracellular cholesterol transporter 1. | Sterol regulatory element binding transcription factor 2. | 0.802 |
PPARG | FASN | ENSFCAP00000050722 | ENSFCAP00000010847 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | Fatty acid synthase. | 0.740 |
PPARG | PPARGC1B | ENSFCAP00000050722 | ENSFCAP00000054930 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | PPARG coactivator 1 beta. | 0.472 |
PPARG | SCD | ENSFCAP00000050722 | ENSFCAP00000025038 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. | 0.684 |
PPARG | SREBF1 | ENSFCAP00000050722 | ENSFCAP00000001834 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | Sterol regulatory element binding transcription factor 1. | 0.767 |
PPARG | SREBF2 | ENSFCAP00000050722 | ENSFCAP00000013258 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | Sterol regulatory element binding transcription factor 2. | 0.686 |
PPARGC1B | PPARG | ENSFCAP00000054930 | ENSFCAP00000050722 | PPARG coactivator 1 beta. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.472 |
PPARGC1B | SREBF1 | ENSFCAP00000054930 | ENSFCAP00000001834 | PPARG coactivator 1 beta. | Sterol regulatory element binding transcription factor 1. | 0.934 |