STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NLRP9NLR family pyrin domain containing 9. (990 aa)    
Predicted Functional Partners:
NAIP
NACHT domain-containing protein.
    
 0.745
CARD8
Caspase recruitment domain family member 8.
 
  
 0.694
PYCARD
PYD and CARD domain containing.
    
 0.681
NLRP6
NLR family pyrin domain containing 6.
     
0.678
GSDMD
Gasdermin D.
     
 0.672
TLE6
TLE family member 6, subcortical maternal complex member.
    
 
 0.659
CASP4
Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]
    
 0.634
CASP12
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 0.613
NLRP3
NLR family pyrin domain containing 3.
     
0.583
MEFV
MEFV innate immuity regulator, pyrin.
    
 0.582
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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