MC5R protein (Felis catus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

MC5R

Melanocortin 5 receptor. (325 aa)

Predicted Functional Partners:

POMC

0.988

MRAP2

0.725

LDLRAD4

0.649

MMRN1

0.647

ENSFCAP00000042560

0.644

AGRP

0.638

LEP

0.590

TFAP2D

0.585

MMRN2

0.559

ASIP

0.547

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRP	LEP	ENSFCAP00000031244	ENSFCAP00000033061	Agouti related neuropeptide.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.799
AGRP	MC5R	ENSFCAP00000031244	ENSFCAP00000002103	Agouti related neuropeptide.	Melanocortin 5 receptor.	0.638
AGRP	MRAP2	ENSFCAP00000031244	ENSFCAP00000006314	Agouti related neuropeptide.	Melanocortin 2 receptor accessory protein 2.	0.471
AGRP	POMC	ENSFCAP00000031244	ENSFCAP00000003372	Agouti related neuropeptide.	Proopiomelanocortin.	0.929
ASIP	MC5R	ENSFCAP00000032069	ENSFCAP00000002103	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Melanocortin 5 receptor.	0.547
ASIP	POMC	ENSFCAP00000032069	ENSFCAP00000003372	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	Proopiomelanocortin.	0.487
ENSFCAP00000042560	MC5R	ENSFCAP00000042560	ENSFCAP00000002103	Uncharacterized protein.	Melanocortin 5 receptor.	0.644
ENSFCAP00000042560	POMC	ENSFCAP00000042560	ENSFCAP00000003372	Uncharacterized protein.	Proopiomelanocortin.	0.808
LDLRAD4	MC5R	ENSFCAP00000023052	ENSFCAP00000002103	Low density lipoprotein receptor class A domain containing 4.	Melanocortin 5 receptor.	0.649
LEP	AGRP	ENSFCAP00000033061	ENSFCAP00000031244	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Agouti related neuropeptide.	0.799
LEP	MC5R	ENSFCAP00000033061	ENSFCAP00000002103	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Melanocortin 5 receptor.	0.590
LEP	POMC	ENSFCAP00000033061	ENSFCAP00000003372	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Proopiomelanocortin.	0.999
MC5R	AGRP	ENSFCAP00000002103	ENSFCAP00000031244	Melanocortin 5 receptor.	Agouti related neuropeptide.	0.638
MC5R	ASIP	ENSFCAP00000002103	ENSFCAP00000032069	Melanocortin 5 receptor.	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).	0.547
MC5R	ENSFCAP00000042560	ENSFCAP00000002103	ENSFCAP00000042560	Melanocortin 5 receptor.	Uncharacterized protein.	0.644
MC5R	LDLRAD4	ENSFCAP00000002103	ENSFCAP00000023052	Melanocortin 5 receptor.	Low density lipoprotein receptor class A domain containing 4.	0.649
MC5R	LEP	ENSFCAP00000002103	ENSFCAP00000033061	Melanocortin 5 receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.590
MC5R	MMRN1	ENSFCAP00000002103	ENSFCAP00000012092	Melanocortin 5 receptor.	Multimerin 1.	0.647
MC5R	MMRN2	ENSFCAP00000002103	ENSFCAP00000057916	Melanocortin 5 receptor.	Multimerin 2.	0.559
MC5R	MRAP2	ENSFCAP00000002103	ENSFCAP00000006314	Melanocortin 5 receptor.	Melanocortin 2 receptor accessory protein 2.	0.725