STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADAM9ADAM metallopeptidase domain 9. (819 aa)    
Predicted Functional Partners:
CCDC66
Coiled-coil domain containing 66.
      
 0.609
PRCD
Photoreceptor disc component.
      
 0.601
RD3
Uncharacterized protein.
      
 0.578
AVL9
AVL9 cell migration associated.
      
 0.544
CNGB3
Cyclic nucleotide gated channel subunit beta 3.
      
 0.518
ADAM17
ADAM metallopeptidase domain 17.
      
0.500
PLEKHA2
Pleckstrin homology domain containing A2.
      
 0.489
APH1B
Uncharacterized protein.
      
 0.455
APP
Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]
     
 0.450
RPE65
Retinoid isomerohydrolase RPE65.
   
  
 0.445
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.