STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (337 aa)    
Predicted Functional Partners:
SERPINA5
Serpin family A member 5; Belongs to the serpin family.
   
 0.559
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 0.557
SERPINB12
Serpin family B member 12; Belongs to the serpin family.
    
 0.552
TMEM63A
Transmembrane protein 63A.
   
  
 0.521
SERPINF2
Serpin family F member 2; Belongs to the serpin family.
   
 0.482
EPHA1
EPH receptor A1.
    
 0.477
GALNT7
Polypeptide N-acetylgalactosaminyltransferase.
     
 0.462
ST3GAL3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3; Belongs to the glycosyltransferase 29 family.
      
 0.455
SPINT2
Serine peptidase inhibitor, Kunitz type 2.
   
 0.446
SERPING1
Serpin family G member 1; Belongs to the serpin family.
   
 0.433
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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