STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)    
Predicted Functional Partners:
FANCM
FA complementation group M.
   
 0.989
TDRD3
Tudor domain containing 3.
    
 0.988
WRN
WRN RecQ like helicase.
  
 0.983
RMI1
RecQ mediated genome instability 1.
    
 0.909
RMI2
RecQ mediated genome instability 2.
    
 0.846
BLM
BLM RecQ like helicase.
  
 0.827
RECQL5
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.813
RPA3
Replication protein A3.
    
 0.796
MUS81
MUS81 structure-specific endonuclease subunit.
    
 0.777
RAD50
Zinc-hook domain-containing protein.
  
 0.756
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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