STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TREM2Triggering receptor expressed on myeloid cells 2. (258 aa)    
Predicted Functional Partners:
TYROBP
TYRO protein tyrosine kinase binding protein.
   
 0.990
SYK
Spleen associated tyrosine kinase.
   
 
 0.963
CD68
Uncharacterized protein.
   
  
 0.932
LOC101085539
Uncharacterized protein.
   
 0.916
SIRPA
Ig-like domain-containing protein.
   
 0.916
ENSFCAP00000040186
Ig-like domain-containing protein.
   
 0.914
CLEC7A
C-type lectin domain containing 7A.
   
 
 0.872
CSF1R
Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...]
   
  
 0.856
TREML1
Triggering receptor expressed on myeloid cells like 1.
 
   
 0.849
C1QA
Complement C1q A chain.
   
  
 0.848
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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