STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAPGCapping actin protein, gelsolin like. (388 aa)    
Predicted Functional Partners:
ANXA2
Annexin.
 
 
  
 0.701
CASP3
Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.
    
 0.614
WAS
WASP actin nucleation promoting factor.
    
 
 0.580
WASL
WASP like actin nucleation promoting factor.
    
 
 0.580
ESPN
Espin.
   
 0.552
COG8
Conserved oligomeric Golgi complex subunit 8; Belongs to the COG8 family.
    
 
 0.524
WHRN
Whirlin.
     
 0.522
CASP7
Caspase 7; Belongs to the peptidase C14A family.
    
 0.508
ESPNL
Espin like.
   
 0.507
CASK
Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.
    
  0.502
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.