DDX5 protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALYREF	DDX17	ENSFCAP00000029154	ENSFCAP00000027708	Aly/REF export factor.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.871
ALYREF	DDX5	ENSFCAP00000029154	ENSFCAP00000003241	Aly/REF export factor.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.929
ALYREF	DHX9	ENSFCAP00000029154	ENSFCAP00000016148	Aly/REF export factor.	DExH-box helicase 9.	0.868
ALYREF	HNRNPK	ENSFCAP00000029154	ENSFCAP00000013786	Aly/REF export factor.	Heterogeneous nuclear ribonucleoprotein K.	0.726
ALYREF	RBM39	ENSFCAP00000029154	ENSFCAP00000018165	Aly/REF export factor.	RNA binding motif protein 39.	0.768
ALYREF	SF3B1	ENSFCAP00000029154	ENSFCAP00000037968	Aly/REF export factor.	Splicing factor 3b subunit 1.	0.417
DDX17	ALYREF	ENSFCAP00000027708	ENSFCAP00000029154	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Aly/REF export factor.	0.871
DDX17	DDX5	ENSFCAP00000027708	ENSFCAP00000003241	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.996
DDX17	DHX9	ENSFCAP00000027708	ENSFCAP00000016148	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DExH-box helicase 9.	0.928
DDX17	DROSHA	ENSFCAP00000027708	ENSFCAP00000050725	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Drosha ribonuclease III.	0.970
DDX17	ESR1	ENSFCAP00000027708	ENSFCAP00000020448	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.891
DDX17	HNRNPK	ENSFCAP00000027708	ENSFCAP00000013786	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Heterogeneous nuclear ribonucleoprotein K.	0.836
DDX17	RBM39	ENSFCAP00000027708	ENSFCAP00000018165	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	RNA binding motif protein 39.	0.894
DDX17	SF3B1	ENSFCAP00000027708	ENSFCAP00000037968	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Splicing factor 3b subunit 1.	0.749
DDX17	SPC24	ENSFCAP00000027708	ENSFCAP00000029812	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	SPC24 component of NDC80 kinetochore complex.	0.423
DDX17	TP53	ENSFCAP00000027708	ENSFCAP00000045749	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.698
DDX5	ALYREF	ENSFCAP00000003241	ENSFCAP00000029154	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Aly/REF export factor.	0.929
DDX5	DDX17	ENSFCAP00000003241	ENSFCAP00000027708	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.996
DDX5	DHX9	ENSFCAP00000003241	ENSFCAP00000016148	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DExH-box helicase 9.	0.991
DDX5	DROSHA	ENSFCAP00000003241	ENSFCAP00000050725	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Drosha ribonuclease III.	0.993