NNT protein (Felis catus) - STRING interaction network

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Score

NNT

Nicotinamide nucleotide transhydrogenase. (1088 aa)

Predicted Functional Partners:

NADK

0.939

NADK2

0.923

NMNAT1

0.917

SIRT3

0.912

NMNAT3

0.910

NADSYN1

0.906

NUDT12

0.904

SIRT5

0.904

SIRT1

0.904

NMNAT2

0.903

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NADK	NADK2	ENSFCAP00000024641	ENSFCAP00000020681	NAD kinase.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	0.948
NADK	NADSYN1	ENSFCAP00000024641	ENSFCAP00000059624	NAD kinase.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.957
NADK	NMNAT1	ENSFCAP00000024641	ENSFCAP00000061938	NAD kinase.	Nicotinamide-nucleotide adenylyltransferase.	0.952
NADK	NMNAT2	ENSFCAP00000024641	ENSFCAP00000044577	NAD kinase.	Nicotinamide nucleotide adenylyltransferase 2.	0.955
NADK	NMNAT3	ENSFCAP00000024641	ENSFCAP00000060020	NAD kinase.	Nicotinamide-nucleotide adenylyltransferase.	0.959
NADK	NNT	ENSFCAP00000024641	ENSFCAP00000003793	NAD kinase.	Nicotinamide nucleotide transhydrogenase.	0.939
NADK	NUDT12	ENSFCAP00000024641	ENSFCAP00000012695	NAD kinase.	Nudix hydrolase 12.	0.914
NADK	SIRT1	ENSFCAP00000024641	ENSFCAP00000027641	NAD kinase.	Sirtuin 1.	0.925
NADK	SIRT3	ENSFCAP00000024641	ENSFCAP00000057030	NAD kinase.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.921
NADK	SIRT5	ENSFCAP00000024641	ENSFCAP00000025698	NAD kinase.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]	0.937
NADK2	NADK	ENSFCAP00000020681	ENSFCAP00000024641	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	NAD kinase.	0.948
NADK2	NADSYN1	ENSFCAP00000020681	ENSFCAP00000059624	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.943
NADK2	NMNAT1	ENSFCAP00000020681	ENSFCAP00000061938	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nicotinamide-nucleotide adenylyltransferase.	0.924
NADK2	NMNAT2	ENSFCAP00000020681	ENSFCAP00000044577	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nicotinamide nucleotide adenylyltransferase 2.	0.921
NADK2	NMNAT3	ENSFCAP00000020681	ENSFCAP00000060020	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nicotinamide-nucleotide adenylyltransferase.	0.936
NADK2	NNT	ENSFCAP00000020681	ENSFCAP00000003793	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nicotinamide nucleotide transhydrogenase.	0.923
NADK2	NUDT12	ENSFCAP00000020681	ENSFCAP00000012695	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nudix hydrolase 12.	0.915
NADK2	SIRT1	ENSFCAP00000020681	ENSFCAP00000027641	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Sirtuin 1.	0.900
NADK2	SIRT3	ENSFCAP00000020681	ENSFCAP00000057030	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.900
NADK2	SIRT5	ENSFCAP00000020681	ENSFCAP00000025698	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]	0.900