| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCL21 | CXCL13 | ENSFCAP00000002912 | ENSFCAP00000054741 | C-C motif chemokine ligand 21. | C-X-C motif chemokine. | 0.994 |
| CCL21 | LTA | ENSFCAP00000002912 | ENSFCAP00000004152 | C-C motif chemokine ligand 21. | Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. | 0.681 |
| CCL21 | LTB | ENSFCAP00000002912 | ENSFCAP00000045551 | C-C motif chemokine ligand 21. | Lymphotoxin beta; Belongs to the tumor necrosis factor family. | 0.483 |
| CCL21 | LTBR | ENSFCAP00000002912 | ENSFCAP00000007966 | C-C motif chemokine ligand 21. | Lymphotoxin beta receptor. | 0.507 |
| CCL21 | TNF | ENSFCAP00000002912 | ENSFCAP00000051032 | C-C motif chemokine ligand 21. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.481 |
| CD40LG | CXCL13 | ENSFCAP00000033038 | ENSFCAP00000054741 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | C-X-C motif chemokine. | 0.538 |
| CD40LG | LTA | ENSFCAP00000033038 | ENSFCAP00000004152 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. | 0.688 |
| CD40LG | LTB | ENSFCAP00000033038 | ENSFCAP00000045551 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Lymphotoxin beta; Belongs to the tumor necrosis factor family. | 0.535 |
| CD40LG | LTBR | ENSFCAP00000033038 | ENSFCAP00000007966 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Lymphotoxin beta receptor. | 0.838 |
| CD40LG | TNF | ENSFCAP00000033038 | ENSFCAP00000051032 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.813 |
| CD40LG | TNFRSF14 | ENSFCAP00000033038 | ENSFCAP00000008830 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | TNF receptor superfamily member 14. | 0.606 |
| CD40LG | TNFRSF1B | ENSFCAP00000033038 | ENSFCAP00000003482 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | TNF receptor superfamily member 1B. | 0.529 |
| CD40LG | TNFSF11 | ENSFCAP00000033038 | ENSFCAP00000005491 | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | TNF superfamily member 11; Belongs to the tumor necrosis factor family. | 0.652 |
| CXCL13 | CCL21 | ENSFCAP00000054741 | ENSFCAP00000002912 | C-X-C motif chemokine. | C-C motif chemokine ligand 21. | 0.994 |
| CXCL13 | CD40LG | ENSFCAP00000054741 | ENSFCAP00000033038 | C-X-C motif chemokine. | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | 0.538 |
| CXCL13 | LTA | ENSFCAP00000054741 | ENSFCAP00000004152 | C-X-C motif chemokine. | Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. | 0.717 |
| CXCL13 | LTB | ENSFCAP00000054741 | ENSFCAP00000045551 | C-X-C motif chemokine. | Lymphotoxin beta; Belongs to the tumor necrosis factor family. | 0.693 |
| CXCL13 | LTBR | ENSFCAP00000054741 | ENSFCAP00000007966 | C-X-C motif chemokine. | Lymphotoxin beta receptor. | 0.493 |
| CXCL13 | TNF | ENSFCAP00000054741 | ENSFCAP00000051032 | C-X-C motif chemokine. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.483 |
| LTA | CCL21 | ENSFCAP00000004152 | ENSFCAP00000002912 | Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. | C-C motif chemokine ligand 21. | 0.681 |