STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
M3W2K3_FELCAPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (236 aa)    
Predicted Functional Partners:
F12
Coagulation factor XII.
  
  0.604
KLK12
Kallikrein related peptidase 12; Belongs to the peptidase S1 family.
  
  
  0.563
HGFAC
HGF activator.
  
  0.560
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 0.557
LOC101098468
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
     0.533
M3WRQ9_FELCA
Peptidase S1 domain-containing protein.
  
 
   0.526
PRSS58
Serine protease 58; Belongs to the peptidase S1 family.
  
     0.521
CTRL
Chymotrypsin like; Belongs to the peptidase S1 family.
 
0.412
LOC101091168
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
0.412
LOC101096371
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
 
0.411
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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