node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACKR1 | CXCL6 | ENSFCAP00000040185 | ENSFCAP00000013886 | Atypical chemokine receptor 1 (Duffy blood group). | C-X-C motif chemokine. | 0.498 |
ACKR1 | CXCL8 | ENSFCAP00000040185 | ENSFCAP00000004310 | Atypical chemokine receptor 1 (Duffy blood group). | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | 0.935 |
ACKR1 | CXCR4 | ENSFCAP00000040185 | ENSFCAP00000060751 | Atypical chemokine receptor 1 (Duffy blood group). | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.413 |
CXCL6 | ACKR1 | ENSFCAP00000013886 | ENSFCAP00000040185 | C-X-C motif chemokine. | Atypical chemokine receptor 1 (Duffy blood group). | 0.498 |
CXCL6 | CXCL8 | ENSFCAP00000013886 | ENSFCAP00000004310 | C-X-C motif chemokine. | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | 0.982 |
CXCL6 | CXCR2 | ENSFCAP00000013886 | ENSFCAP00000025385 | C-X-C motif chemokine. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.980 |
CXCL6 | CXCR4 | ENSFCAP00000013886 | ENSFCAP00000060751 | C-X-C motif chemokine. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.951 |
CXCL6 | IL1B | ENSFCAP00000013886 | ENSFCAP00000005482 | C-X-C motif chemokine. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.653 |
CXCL6 | LOC101085650 | ENSFCAP00000013886 | ENSFCAP00000028601 | C-X-C motif chemokine. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.980 |
CXCL6 | LOC101094344 | ENSFCAP00000013886 | ENSFCAP00000057238 | C-X-C motif chemokine. | C-X-C motif chemokine. | 0.975 |
CXCL8 | ACKR1 | ENSFCAP00000004310 | ENSFCAP00000040185 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | Atypical chemokine receptor 1 (Duffy blood group). | 0.935 |
CXCL8 | CXCL6 | ENSFCAP00000004310 | ENSFCAP00000013886 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | C-X-C motif chemokine. | 0.982 |
CXCL8 | CXCR2 | ENSFCAP00000004310 | ENSFCAP00000025385 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.965 |
CXCL8 | CXCR4 | ENSFCAP00000004310 | ENSFCAP00000060751 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.841 |
CXCL8 | IL1B | ENSFCAP00000004310 | ENSFCAP00000005482 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.953 |
CXCL8 | JUN | ENSFCAP00000004310 | ENSFCAP00000021043 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.914 |
CXCL8 | LOC101085650 | ENSFCAP00000004310 | ENSFCAP00000028601 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.965 |
CXCL8 | LOC101094344 | ENSFCAP00000004310 | ENSFCAP00000057238 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | C-X-C motif chemokine. | 0.962 |
CXCL8 | NFKB1 | ENSFCAP00000004310 | ENSFCAP00000006998 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | Nuclear factor kappa B subunit 1. | 0.938 |
CXCL8 | RELA | ENSFCAP00000004310 | ENSFCAP00000048226 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. | RELA proto-oncogene, NF-kB subunit. | 0.901 |