STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLAURPlasminogen activator, urokinase receptor. (335 aa)    
Predicted Functional Partners:
PLAU
Plasminogen activator, urokinase.
   
 0.999
VTN
SMB domain-containing protein.
    
 0.964
PLAT
Plasminogen activator; Belongs to the peptidase S1 family.
   
 0.950
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
    
 0.939
SERPINE1
Serpin family E member 1; Belongs to the serpin family.
   
 0.913
SERPINB2
Serpin family B member 2; Belongs to the serpin family.
   
 0.730
PINLYP
Phospholipase A2 inhibitor and LY6/PLAUR domain containing.
     
 0.597
MMP9
Matrix metallopeptidase 9.
   
 
 0.595
SERPINE2
Serpin family E member 2; Belongs to the serpin family.
   
 0.588
IQGAP2
IQ motif containing GTPase activating protein 2.
   
  
 0.586
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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