TNFSF11 protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TNFSF11

TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)

Predicted Functional Partners:

TNFRSF11B

0.998

TNFRSF11A

0.998

TGFB2

0.764

LTBR

0.763

CD40

0.723

TNFSF13B

0.713

TNFRSF18

0.689

TNFRSF14

0.689

LTA

0.660

CD40LG

0.652

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD40	CD40LG	ENSFCAP00000013000	ENSFCAP00000033038	CD40 molecule.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.999
CD40	LTA	ENSFCAP00000013000	ENSFCAP00000004152	CD40 molecule.	Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family.	0.625
CD40	TNFRSF11A	ENSFCAP00000013000	ENSFCAP00000059831	CD40 molecule.	TNF receptor superfamily member 11a.	0.487
CD40	TNFSF11	ENSFCAP00000013000	ENSFCAP00000005491	CD40 molecule.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.723
CD40	TNFSF13B	ENSFCAP00000013000	ENSFCAP00000022051	CD40 molecule.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.650
CD40LG	CD40	ENSFCAP00000033038	ENSFCAP00000013000	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	CD40 molecule.	0.999
CD40LG	LTA	ENSFCAP00000033038	ENSFCAP00000004152	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family.	0.688
CD40LG	LTBR	ENSFCAP00000033038	ENSFCAP00000007966	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	Lymphotoxin beta receptor.	0.838
CD40LG	TNFRSF11A	ENSFCAP00000033038	ENSFCAP00000059831	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	TNF receptor superfamily member 11a.	0.527
CD40LG	TNFRSF11B	ENSFCAP00000033038	ENSFCAP00000055235	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	TNF receptor superfamily member 11b.	0.588
CD40LG	TNFRSF14	ENSFCAP00000033038	ENSFCAP00000008830	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	TNF receptor superfamily member 14.	0.606
CD40LG	TNFRSF18	ENSFCAP00000033038	ENSFCAP00000008637	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	TNF receptor superfamily member 18.	0.588
CD40LG	TNFSF11	ENSFCAP00000033038	ENSFCAP00000005491	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.652
CD40LG	TNFSF13B	ENSFCAP00000033038	ENSFCAP00000022051	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.735
LTA	CD40	ENSFCAP00000004152	ENSFCAP00000013000	Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family.	CD40 molecule.	0.625
LTA	CD40LG	ENSFCAP00000004152	ENSFCAP00000033038	Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.688
LTA	LTBR	ENSFCAP00000004152	ENSFCAP00000007966	Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family.	Lymphotoxin beta receptor.	0.990
LTA	TNFRSF11B	ENSFCAP00000004152	ENSFCAP00000055235	Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family.	TNF receptor superfamily member 11b.	0.494
LTA	TNFRSF14	ENSFCAP00000004152	ENSFCAP00000008830	Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family.	TNF receptor superfamily member 14.	0.947
LTA	TNFRSF18	ENSFCAP00000004152	ENSFCAP00000008637	Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family.	TNF receptor superfamily member 18.	0.462