node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DPP4 | FAP | ENSFCAP00000037887 | ENSFCAP00000021631 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | 0.956 |
DPP4 | GCG | ENSFCAP00000037887 | ENSFCAP00000040171 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | Glucagon. | 0.759 |
DPP4 | GIP | ENSFCAP00000037887 | ENSFCAP00000008291 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | GLUCAGON domain-containing protein. | 0.971 |
DPP4 | GLP1R | ENSFCAP00000037887 | ENSFCAP00000005956 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. | 0.887 |
DPP4 | GLP2R | ENSFCAP00000037887 | ENSFCAP00000001707 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | Glucagon like peptide 2 receptor. | 0.600 |
DPP4 | GNAS | ENSFCAP00000037887 | ENSFCAP00000053225 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | GNAS complex locus. | 0.450 |
FAP | DPP4 | ENSFCAP00000021631 | ENSFCAP00000037887 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | 0.956 |
FAP | GCG | ENSFCAP00000021631 | ENSFCAP00000040171 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Glucagon. | 0.607 |
FAP | GIP | ENSFCAP00000021631 | ENSFCAP00000008291 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | GLUCAGON domain-containing protein. | 0.804 |
FAP | GLP1R | ENSFCAP00000021631 | ENSFCAP00000005956 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. | 0.989 |
FAP | GLP2R | ENSFCAP00000021631 | ENSFCAP00000001707 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Glucagon like peptide 2 receptor. | 0.962 |
FAP | GNAS | ENSFCAP00000021631 | ENSFCAP00000053225 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | GNAS complex locus. | 0.608 |
FAP | POMC | ENSFCAP00000021631 | ENSFCAP00000003372 | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | Proopiomelanocortin. | 0.489 |
GCG | DPP4 | ENSFCAP00000040171 | ENSFCAP00000037887 | Glucagon. | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] | 0.759 |
GCG | FAP | ENSFCAP00000040171 | ENSFCAP00000021631 | Glucagon. | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. | 0.607 |
GCG | GIP | ENSFCAP00000040171 | ENSFCAP00000008291 | Glucagon. | GLUCAGON domain-containing protein. | 0.599 |
GCG | GLP1R | ENSFCAP00000040171 | ENSFCAP00000005956 | Glucagon. | Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. | 0.989 |
GCG | GLP2R | ENSFCAP00000040171 | ENSFCAP00000001707 | Glucagon. | Glucagon like peptide 2 receptor. | 0.973 |
GCG | GNAS | ENSFCAP00000040171 | ENSFCAP00000053225 | Glucagon. | GNAS complex locus. | 0.525 |
GCG | POMC | ENSFCAP00000040171 | ENSFCAP00000003372 | Glucagon. | Proopiomelanocortin. | 0.415 |