DGCR8 protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	DDX5	ENSFCAP00000002557	ENSFCAP00000003241	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.420
AGO2	DGCR8	ENSFCAP00000002557	ENSFCAP00000027619	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DGCR8 microprocessor complex subunit.	0.746
AGO2	DICER1	ENSFCAP00000002557	ENSFCAP00000039586	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.996
AGO2	DROSHA	ENSFCAP00000002557	ENSFCAP00000050725	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Drosha ribonuclease III.	0.870
AGO2	XPO5	ENSFCAP00000002557	ENSFCAP00000031162	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Exportin 5.	0.830
DDX17	DDX5	ENSFCAP00000027708	ENSFCAP00000003241	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.996
DDX17	DGCR8	ENSFCAP00000027708	ENSFCAP00000027619	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DGCR8 microprocessor complex subunit.	0.759
DDX17	DICER1	ENSFCAP00000027708	ENSFCAP00000039586	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.408
DDX17	DROSHA	ENSFCAP00000027708	ENSFCAP00000050725	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Drosha ribonuclease III.	0.970
DDX17	RPL3	ENSFCAP00000027708	ENSFCAP00000005405	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	0.401
DDX5	AGO2	ENSFCAP00000003241	ENSFCAP00000002557	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.420
DDX5	DDX17	ENSFCAP00000003241	ENSFCAP00000027708	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.996
DDX5	DGCR8	ENSFCAP00000003241	ENSFCAP00000027619	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DGCR8 microprocessor complex subunit.	0.748
DDX5	DROSHA	ENSFCAP00000003241	ENSFCAP00000050725	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Drosha ribonuclease III.	0.993
DDX5	RPL3	ENSFCAP00000003241	ENSFCAP00000005405	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.	0.471
DGCR8	AGO2	ENSFCAP00000027619	ENSFCAP00000002557	DGCR8 microprocessor complex subunit.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.746
DGCR8	DDX17	ENSFCAP00000027619	ENSFCAP00000027708	DGCR8 microprocessor complex subunit.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.759
DGCR8	DDX5	ENSFCAP00000027619	ENSFCAP00000003241	DGCR8 microprocessor complex subunit.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.748
DGCR8	DICER1	ENSFCAP00000027619	ENSFCAP00000039586	DGCR8 microprocessor complex subunit.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.900
DGCR8	DNA2	ENSFCAP00000027619	ENSFCAP00000010080	DGCR8 microprocessor complex subunit.	DNA replication helicase/nuclease 2.	0.711