SLC8A1 protein (Felis catus) - STRING interaction network

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SLC8A1

Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation- contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (973 aa)

Predicted Functional Partners:

SLC8A2

0.915

PRKACA

0.909

PRKACB

0.909

PRKG1

0.906

PRKG2

0.905

SLC8A3

0.901

CACNA1D

0.691

TRA2B

0.658

CYP4V2

0.650

DGKG

0.647

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNA1D	PRKACA	ENSFCAP00000051767	ENSFCAP00000018754	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.913
CACNA1D	PRKACB	ENSFCAP00000051767	ENSFCAP00000040413	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.913
CACNA1D	PRKG1	ENSFCAP00000051767	ENSFCAP00000029065	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	cGMP-dependent protein kinase.	0.909
CACNA1D	PRKG2	ENSFCAP00000051767	ENSFCAP00000007237	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	cGMP-dependent protein kinase.	0.913
CACNA1D	SLC8A1	ENSFCAP00000051767	ENSFCAP00000041112	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation- contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...]	0.691
CYP4V2	SLC8A1	ENSFCAP00000001436	ENSFCAP00000041112	Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family.	Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation- contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...]	0.650
DGKG	SLC8A1	ENSFCAP00000034305	ENSFCAP00000041112	Diacylglycerol kinase.	Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation- contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...]	0.647
DGKG	TRA2B	ENSFCAP00000034305	ENSFCAP00000009773	Diacylglycerol kinase.	Transformer 2 beta homolog.	0.793
PRKACA	CACNA1D	ENSFCAP00000018754	ENSFCAP00000051767	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.913
PRKACA	PRKACB	ENSFCAP00000018754	ENSFCAP00000040413	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.900
PRKACA	PRKG1	ENSFCAP00000018754	ENSFCAP00000029065	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	cGMP-dependent protein kinase.	0.611
PRKACA	PRKG2	ENSFCAP00000018754	ENSFCAP00000007237	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	cGMP-dependent protein kinase.	0.611
PRKACA	SLC8A1	ENSFCAP00000018754	ENSFCAP00000041112	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation- contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...]	0.909
PRKACA	SLC8A2	ENSFCAP00000018754	ENSFCAP00000023617	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.903
PRKACA	SLC8A3	ENSFCAP00000018754	ENSFCAP00000039620	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.909
PRKACB	CACNA1D	ENSFCAP00000040413	ENSFCAP00000051767	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.913
PRKACB	PRKACA	ENSFCAP00000040413	ENSFCAP00000018754	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.900
PRKACB	PRKG1	ENSFCAP00000040413	ENSFCAP00000029065	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	cGMP-dependent protein kinase.	0.613
PRKACB	PRKG2	ENSFCAP00000040413	ENSFCAP00000007237	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	cGMP-dependent protein kinase.	0.614
PRKACB	SLC8A1	ENSFCAP00000040413	ENSFCAP00000041112	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation- contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...]	0.909

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