| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BAG4 | RIPK1 | ENSFCAP00000042388 | ENSFCAP00000013566 | BCL2 associated athanogene 4. | Receptor interacting serine/threonine kinase 1. | 0.531 |
| BAG4 | TNF | ENSFCAP00000042388 | ENSFCAP00000051032 | BCL2 associated athanogene 4. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.443 |
| BAG4 | TNFRSF1A | ENSFCAP00000042388 | ENSFCAP00000006375 | BCL2 associated athanogene 4. | TNF receptor superfamily member 1A. | 0.995 |
| BAG4 | TRADD | ENSFCAP00000042388 | ENSFCAP00000045608 | BCL2 associated athanogene 4. | TNFRSF1A associated via death domain. | 0.625 |
| BAG4 | TRAF2 | ENSFCAP00000042388 | ENSFCAP00000000359 | BCL2 associated athanogene 4. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.522 |
| BIRC3 | FADD | ENSFCAP00000013003 | ENSFCAP00000045141 | Baculoviral IAP repeat containing 3. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.951 |
| BIRC3 | IKBKB | ENSFCAP00000013003 | ENSFCAP00000044529 | Baculoviral IAP repeat containing 3. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.551 |
| BIRC3 | LTA | ENSFCAP00000013003 | ENSFCAP00000004152 | Baculoviral IAP repeat containing 3. | Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. | 0.416 |
| BIRC3 | RIPK1 | ENSFCAP00000013003 | ENSFCAP00000013566 | Baculoviral IAP repeat containing 3. | Receptor interacting serine/threonine kinase 1. | 0.984 |
| BIRC3 | TNF | ENSFCAP00000013003 | ENSFCAP00000051032 | Baculoviral IAP repeat containing 3. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.913 |
| BIRC3 | TNFRSF1A | ENSFCAP00000013003 | ENSFCAP00000006375 | Baculoviral IAP repeat containing 3. | TNF receptor superfamily member 1A. | 0.991 |
| BIRC3 | TRADD | ENSFCAP00000013003 | ENSFCAP00000045608 | Baculoviral IAP repeat containing 3. | TNFRSF1A associated via death domain. | 0.987 |
| BIRC3 | TRAF2 | ENSFCAP00000013003 | ENSFCAP00000000359 | Baculoviral IAP repeat containing 3. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.997 |
| FADD | BIRC3 | ENSFCAP00000045141 | ENSFCAP00000013003 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Baculoviral IAP repeat containing 3. | 0.951 |
| FADD | IKBKB | ENSFCAP00000045141 | ENSFCAP00000044529 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.611 |
| FADD | RIPK1 | ENSFCAP00000045141 | ENSFCAP00000013566 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Receptor interacting serine/threonine kinase 1. | 0.999 |
| FADD | TNF | ENSFCAP00000045141 | ENSFCAP00000051032 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.802 |
| FADD | TNFRSF1A | ENSFCAP00000045141 | ENSFCAP00000006375 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNF receptor superfamily member 1A. | 0.991 |
| FADD | TRADD | ENSFCAP00000045141 | ENSFCAP00000045608 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNFRSF1A associated via death domain. | 0.999 |
| FADD | TRAF2 | ENSFCAP00000045141 | ENSFCAP00000000359 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.994 |