| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALCAM | CD14 | ENSFCAP00000006522 | ENSFCAP00000001187 | Activated leukocyte cell adhesion molecule. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.528 |
| ALCAM | CD3E | ENSFCAP00000006522 | ENSFCAP00000059396 | Activated leukocyte cell adhesion molecule. | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] | 0.436 |
| ALCAM | CD5 | ENSFCAP00000006522 | ENSFCAP00000058658 | Activated leukocyte cell adhesion molecule. | CD5 molecule. | 0.486 |
| ALCAM | CD6 | ENSFCAP00000006522 | ENSFCAP00000012679 | Activated leukocyte cell adhesion molecule. | CD6 molecule. | 0.908 |
| ALCAM | CDCP1 | ENSFCAP00000006522 | ENSFCAP00000022116 | Activated leukocyte cell adhesion molecule. | CUB domain containing protein 1. | 0.452 |
| ALCAM | ITGB1 | ENSFCAP00000006522 | ENSFCAP00000031914 | Activated leukocyte cell adhesion molecule. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.486 |
| ALCAM | MKI67 | ENSFCAP00000006522 | ENSFCAP00000059248 | Activated leukocyte cell adhesion molecule. | FHA domain-containing protein. | 0.446 |
| ALCAM | PTPN6 | ENSFCAP00000006522 | ENSFCAP00000003953 | Activated leukocyte cell adhesion molecule. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.472 |
| ALCAM | RHOA | ENSFCAP00000006522 | ENSFCAP00000017917 | Activated leukocyte cell adhesion molecule. | Ras homolog family member A. | 0.469 |
| ALCAM | RHOF | ENSFCAP00000006522 | ENSFCAP00000001241 | Activated leukocyte cell adhesion molecule. | Ras homolog family member F, filopodia associated. | 0.444 |
| CD14 | ALCAM | ENSFCAP00000001187 | ENSFCAP00000006522 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Activated leukocyte cell adhesion molecule. | 0.528 |
| CD3E | ALCAM | ENSFCAP00000059396 | ENSFCAP00000006522 | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] | Activated leukocyte cell adhesion molecule. | 0.436 |
| CD3E | CD5 | ENSFCAP00000059396 | ENSFCAP00000058658 | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] | CD5 molecule. | 0.852 |
| CD3E | CD6 | ENSFCAP00000059396 | ENSFCAP00000012679 | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] | CD6 molecule. | 0.819 |
| CD3E | PTPN6 | ENSFCAP00000059396 | ENSFCAP00000003953 | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.715 |
| CD5 | ALCAM | ENSFCAP00000058658 | ENSFCAP00000006522 | CD5 molecule. | Activated leukocyte cell adhesion molecule. | 0.486 |
| CD5 | CD3E | ENSFCAP00000058658 | ENSFCAP00000059396 | CD5 molecule. | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] | 0.852 |
| CD5 | CD6 | ENSFCAP00000058658 | ENSFCAP00000012679 | CD5 molecule. | CD6 molecule. | 0.928 |
| CD6 | ALCAM | ENSFCAP00000012679 | ENSFCAP00000006522 | CD6 molecule. | Activated leukocyte cell adhesion molecule. | 0.908 |
| CD6 | CD3E | ENSFCAP00000012679 | ENSFCAP00000059396 | CD6 molecule. | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] | 0.819 |