| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGRP | GHRL | ENSFCAP00000031244 | ENSFCAP00000010442 | Agouti related neuropeptide. | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | 0.811 |
| AGRP | LEP | ENSFCAP00000031244 | ENSFCAP00000033061 | Agouti related neuropeptide. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.799 |
| AGRP | MC3R | ENSFCAP00000031244 | ENSFCAP00000006543 | Agouti related neuropeptide. | Melanocortin 3 receptor. | 0.851 |
| AGRP | MRAP2 | ENSFCAP00000031244 | ENSFCAP00000006314 | Agouti related neuropeptide. | Melanocortin 2 receptor accessory protein 2. | 0.471 |
| AGRP | NPY | ENSFCAP00000031244 | ENSFCAP00000061193 | Agouti related neuropeptide. | Neuropeptide Y; Belongs to the NPY family. | 0.899 |
| AGRP | POMC | ENSFCAP00000031244 | ENSFCAP00000003372 | Agouti related neuropeptide. | Proopiomelanocortin. | 0.929 |
| AGRP | ZFR | ENSFCAP00000031244 | ENSFCAP00000000326 | Agouti related neuropeptide. | Zinc finger RNA binding protein. | 0.406 |
| ALB | GHRL | ENSFCAP00000028536 | ENSFCAP00000010442 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | 0.455 |
| ALB | LEP | ENSFCAP00000028536 | ENSFCAP00000033061 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.724 |
| ALB | MC3R | ENSFCAP00000028536 | ENSFCAP00000006543 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Melanocortin 3 receptor. | 0.587 |
| ALB | NPY | ENSFCAP00000028536 | ENSFCAP00000061193 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Neuropeptide Y; Belongs to the NPY family. | 0.567 |
| ALB | POMC | ENSFCAP00000028536 | ENSFCAP00000003372 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | Proopiomelanocortin. | 0.724 |
| CBLN4 | MC3R | ENSFCAP00000006542 | ENSFCAP00000006543 | C1q domain-containing protein. | Melanocortin 3 receptor. | 0.549 |
| GHRL | AGRP | ENSFCAP00000010442 | ENSFCAP00000031244 | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | Agouti related neuropeptide. | 0.811 |
| GHRL | ALB | ENSFCAP00000010442 | ENSFCAP00000028536 | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] | 0.455 |
| GHRL | LEP | ENSFCAP00000010442 | ENSFCAP00000033061 | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.987 |
| GHRL | MC3R | ENSFCAP00000010442 | ENSFCAP00000006543 | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | Melanocortin 3 receptor. | 0.567 |
| GHRL | NPY | ENSFCAP00000010442 | ENSFCAP00000061193 | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | Neuropeptide Y; Belongs to the NPY family. | 0.871 |
| GHRL | POMC | ENSFCAP00000010442 | ENSFCAP00000003372 | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | Proopiomelanocortin. | 0.966 |
| LEP | AGRP | ENSFCAP00000033061 | ENSFCAP00000031244 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Agouti related neuropeptide. | 0.799 |