STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTSFCathepsin F; Belongs to the peptidase C1 family. (459 aa)    
Predicted Functional Partners:
BID
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
   
 
  0.901
BCL2L1
BCL2 like 1.
     
 0.901
BCL2
BCL2 apoptosis regulator.
     
 0.901
CTSD
Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.
   
 0.822
CTSB
Cathepsin B; Belongs to the peptidase C1 family.
  
0.741
METAP2
Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
   
 
 0.673
XIAP
X-linked inhibitor of apoptosis.
     
 0.656
BIRC3
Baculoviral IAP repeat containing 3.
     
 0.656
BIRC5
Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]
     
 0.656
MFSD8
Major facilitator superfamily domain containing 8.
      
 0.649
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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