STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIGIRRSingle Ig and TIR domain containing. (410 aa)    
Predicted Functional Partners:
TOLLIP
Toll interacting protein.
    
 
 0.767
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
    
 0.737
UNC79
Unc-79 homolog, NALCN channel complex subunit.
    
 0.713
TLR2
Toll like receptor 2; Belongs to the Toll-like receptor family.
    
0.666
LRRC25
Leucine rich repeat containing 25.
    
 0.614
RUVBL1
RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.
    
 0.612
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.609
IL18R1
Interleukin 18 receptor 1.
   
 
0.585
SLC4A3
Anion exchange protein.
      
 0.549
TLR6
Toll like receptor 6; Belongs to the Toll-like receptor family.
    
 0.540
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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