STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRSS57Serine protease 57; Belongs to the peptidase S1 family. (283 aa)    
Predicted Functional Partners:
MILR1
Mast cell immunoglobulin like receptor 1.
   
 0.784
HIGD2A
HIG1 domain-containing protein.
      
 0.754
CCM2
CCM2 scaffold protein.
    
 0.671
PPP1R27
Protein phosphatase 1 regulatory subunit 27.
    
 0.621
CBFA2T3
CBFA2/RUNX1 partner transcriptional co-repressor 3.
    
 
 0.618
MYO1G
Myosin IG; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
      
 0.608
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 0.557
MAP3K3
Uncharacterized protein.
    
 
 0.548
LOC101082541
Olfactory receptor.
    
 0.519
SH2D3C
SH2 domain containing 3C.
    
 0.494
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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