TMPRSS2 protein (Felis catus) - STRING interaction network

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TMPRSS2

Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)

Predicted Functional Partners:

ACE2

0.947

PDP

0.880

LOC101087880

0.878

LOC101101202

0.878

LOC105259631

0.878

CTSV

0.878

FURIN

0.877

LOC111559123

0.876

LOC101082891

0.876

AR

0.857

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	CTSV	ENSFCAP00000052000	ENSFCAP00000036179	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Cathepsin V; Belongs to the peptidase C1 family.	0.718
ACE2	FURIN	ENSFCAP00000052000	ENSFCAP00000059575	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.885
ACE2	LOC101082891	ENSFCAP00000052000	ENSFCAP00000038904	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Uncharacterized protein; Belongs to the peptidase C1 family.	0.650
ACE2	LOC101087880	ENSFCAP00000052000	ENSFCAP00000001633	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Uncharacterized protein; Belongs to the peptidase C1 family.	0.657
ACE2	LOC101101202	ENSFCAP00000052000	ENSFCAP00000015341	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Uncharacterized protein; Belongs to the peptidase C1 family.	0.653
ACE2	LOC105259631	ENSFCAP00000052000	ENSFCAP00000024996	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Uncharacterized protein; Belongs to the peptidase C1 family.	0.653
ACE2	LOC111559123	ENSFCAP00000052000	ENSFCAP00000031669	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Uncharacterized protein; Belongs to the peptidase C1 family.	0.650
ACE2	PDP	ENSFCAP00000052000	ENSFCAP00000019080	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Cathepsin L1; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family.	0.654
ACE2	TMPRSS2	ENSFCAP00000052000	ENSFCAP00000007479	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.947
AR	TMPRSS2	ENSFCAP00000006793	ENSFCAP00000007479	Androgen receptor.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.857
CTSV	ACE2	ENSFCAP00000036179	ENSFCAP00000052000	Cathepsin V; Belongs to the peptidase C1 family.	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	0.718
CTSV	FURIN	ENSFCAP00000036179	ENSFCAP00000059575	Cathepsin V; Belongs to the peptidase C1 family.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.750
CTSV	TMPRSS2	ENSFCAP00000036179	ENSFCAP00000007479	Cathepsin V; Belongs to the peptidase C1 family.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.878
FURIN	ACE2	ENSFCAP00000059575	ENSFCAP00000052000	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	0.885
FURIN	CTSV	ENSFCAP00000059575	ENSFCAP00000036179	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Cathepsin V; Belongs to the peptidase C1 family.	0.750
FURIN	LOC101082891	ENSFCAP00000059575	ENSFCAP00000038904	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.736
FURIN	LOC101087880	ENSFCAP00000059575	ENSFCAP00000001633	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.748
FURIN	LOC101101202	ENSFCAP00000059575	ENSFCAP00000015341	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.747
FURIN	LOC105259631	ENSFCAP00000059575	ENSFCAP00000024996	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.747
FURIN	LOC111559123	ENSFCAP00000059575	ENSFCAP00000031669	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.736