STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (296 aa)    
Predicted Functional Partners:
SPINK5
Serine peptidase inhibitor, Kazal type 5.
   
 0.960
SPINK9
Serine peptidase inhibitor, Kazal type 9.
    
 0.930
SPINK6
Serine peptidase inhibitor, Kazal type 6.
    
 0.916
KLK7
Kallikrein related peptidase 7; Belongs to the peptidase S1 family.
  
 
0.709
CTRC
Chymotrypsin C; Belongs to the peptidase S1 family.
  
 
 
0.654
KLK8
Kallikrein related peptidase 8; Belongs to the peptidase S1 family.
  
 
 
0.630
TMPRSS4
Transmembrane serine protease 4; Belongs to the peptidase S1 family.
  
 
 
 0.627
SERPINB12
Serpin family B member 12; Belongs to the serpin family.
   
 0.620
APP
Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]
    
 0.565
CDSN
Corneodesmosin.
   
 
 0.561
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.