STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAXIP1PAX interacting protein 1. (1016 aa)    
Predicted Functional Partners:
RIF1
Replication timing regulatory factor 1.
   
 0.939
PAGR1
PAXIP1 associated glutamate rich protein 1.
    
 0.908
KDM6A
Lysine demethylase 6A.
   
 0.900
TP53BP1
Tumor protein p53 binding protein 1.
    
 0.900
KDM6B
Lysine demethylase 6B.
   
 0.895
ATM
Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]
   
 0.870
SMC6
Structural maintenance of chromosomes 6.
   
 
 0.862
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
   
 0.838
ASH2L
ASH2 like, histone lysine methyltransferase complex subunit.
    
 0.835
SLF1
SMC5-SMC6 complex localization factor 1.
   
 0.831
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.