node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FOXP3 | IFNG | ENSFCAP00000043740 | ENSFCAP00000008355 | Forkhead box P3. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.972 |
FOXP3 | IL10 | ENSFCAP00000043740 | ENSFCAP00000012535 | Forkhead box P3. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.882 |
FOXP3 | IL1B | ENSFCAP00000043740 | ENSFCAP00000005482 | Forkhead box P3. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.676 |
FOXP3 | IL2 | ENSFCAP00000043740 | ENSFCAP00000012696 | Forkhead box P3. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.932 |
IFNAR1 | IFNAR2 | ENSFCAP00000025378 | ENSFCAP00000017113 | Interferon alpha and beta receptor subunit 1. | Uncharacterized protein. | 0.999 |
IFNAR1 | IFNG | ENSFCAP00000025378 | ENSFCAP00000008355 | Interferon alpha and beta receptor subunit 1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.975 |
IFNAR1 | IFNGR1 | ENSFCAP00000025378 | ENSFCAP00000023535 | Interferon alpha and beta receptor subunit 1. | Interferon gamma receptor 1. | 0.938 |
IFNAR1 | IFNGR2 | ENSFCAP00000025378 | ENSFCAP00000039595 | Interferon alpha and beta receptor subunit 1. | Interferon gamma receptor 2. | 0.940 |
IFNAR1 | IL10 | ENSFCAP00000025378 | ENSFCAP00000012535 | Interferon alpha and beta receptor subunit 1. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.922 |
IFNAR1 | IL1B | ENSFCAP00000025378 | ENSFCAP00000005482 | Interferon alpha and beta receptor subunit 1. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.511 |
IFNAR1 | IL2 | ENSFCAP00000025378 | ENSFCAP00000012696 | Interferon alpha and beta receptor subunit 1. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.757 |
IFNAR1 | JAK1 | ENSFCAP00000025378 | ENSFCAP00000001806 | Interferon alpha and beta receptor subunit 1. | Tyrosine-protein kinase. | 0.997 |
IFNAR1 | JAK2 | ENSFCAP00000025378 | ENSFCAP00000049673 | Interferon alpha and beta receptor subunit 1. | Tyrosine-protein kinase. | 0.972 |
IFNAR2 | IFNAR1 | ENSFCAP00000017113 | ENSFCAP00000025378 | Uncharacterized protein. | Interferon alpha and beta receptor subunit 1. | 0.999 |
IFNAR2 | IFNG | ENSFCAP00000017113 | ENSFCAP00000008355 | Uncharacterized protein. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.954 |
IFNAR2 | IFNGR1 | ENSFCAP00000017113 | ENSFCAP00000023535 | Uncharacterized protein. | Interferon gamma receptor 1. | 0.945 |
IFNAR2 | IFNGR2 | ENSFCAP00000017113 | ENSFCAP00000039595 | Uncharacterized protein. | Interferon gamma receptor 2. | 0.945 |
IFNAR2 | IL10 | ENSFCAP00000017113 | ENSFCAP00000012535 | Uncharacterized protein. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.726 |
IFNAR2 | IL2 | ENSFCAP00000017113 | ENSFCAP00000012696 | Uncharacterized protein. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.679 |
IFNAR2 | JAK1 | ENSFCAP00000017113 | ENSFCAP00000001806 | Uncharacterized protein. | Tyrosine-protein kinase. | 0.998 |