IWS1 protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

IWS1

Interacts with SUPT6H, CTD assembly factor 1. (873 aa)

Predicted Functional Partners:

SUPT6H

0.994

TCEA1

0.953

SSRP1

0.949

CTDP1

0.941

CTR9

0.940

EAF1

0.935

SUPT16H

0.927

AFF4

0.923

EAF2

0.914

LEO1

0.910

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFF4	CTDP1	ENSFCAP00000011526	ENSFCAP00000000525	AF4/FMR2 family member 4.	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	0.884
AFF4	CTR9	ENSFCAP00000011526	ENSFCAP00000000377	AF4/FMR2 family member 4.	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.590
AFF4	EAF1	ENSFCAP00000011526	ENSFCAP00000056093	AF4/FMR2 family member 4.	ELL associated factor 1.	0.993
AFF4	EAF2	ENSFCAP00000011526	ENSFCAP00000015797	AF4/FMR2 family member 4.	ELL associated factor 2.	0.993
AFF4	IWS1	ENSFCAP00000011526	ENSFCAP00000008367	AF4/FMR2 family member 4.	Interacts with SUPT6H, CTD assembly factor 1.	0.923
AFF4	LEO1	ENSFCAP00000011526	ENSFCAP00000019337	AF4/FMR2 family member 4.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.481
AFF4	SSRP1	ENSFCAP00000011526	ENSFCAP00000059840	AF4/FMR2 family member 4.	Tankyrase 1 binding protein 1.	0.483
AFF4	SUPT16H	ENSFCAP00000011526	ENSFCAP00000012851	AF4/FMR2 family member 4.	SPT16 homolog, facilitates chromatin remodeling subunit.	0.498
AFF4	SUPT6H	ENSFCAP00000011526	ENSFCAP00000003707	AF4/FMR2 family member 4.	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family.	0.920
AFF4	TCEA1	ENSFCAP00000011526	ENSFCAP00000050186	AF4/FMR2 family member 4.	Uncharacterized protein.	0.910
CTDP1	AFF4	ENSFCAP00000000525	ENSFCAP00000011526	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	AF4/FMR2 family member 4.	0.884
CTDP1	EAF1	ENSFCAP00000000525	ENSFCAP00000056093	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	ELL associated factor 1.	0.935
CTDP1	EAF2	ENSFCAP00000000525	ENSFCAP00000015797	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	ELL associated factor 2.	0.902
CTDP1	IWS1	ENSFCAP00000000525	ENSFCAP00000008367	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Interacts with SUPT6H, CTD assembly factor 1.	0.941
CTDP1	SSRP1	ENSFCAP00000000525	ENSFCAP00000059840	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Tankyrase 1 binding protein 1.	0.679
CTDP1	SUPT16H	ENSFCAP00000000525	ENSFCAP00000012851	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	SPT16 homolog, facilitates chromatin remodeling subunit.	0.694
CTDP1	SUPT6H	ENSFCAP00000000525	ENSFCAP00000003707	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family.	0.954
CTDP1	TCEA1	ENSFCAP00000000525	ENSFCAP00000050186	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.875
CTR9	AFF4	ENSFCAP00000000377	ENSFCAP00000011526	CTR9 homolog, Paf1/RNA polymerase II complex component.	AF4/FMR2 family member 4.	0.590
CTR9	IWS1	ENSFCAP00000000377	ENSFCAP00000008367	CTR9 homolog, Paf1/RNA polymerase II complex component.	Interacts with SUPT6H, CTD assembly factor 1.	0.940