Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANAPC7 | DSCC1 | ENSFCAP00000020067 | ENSFCAP00000010167 | Anaphase promoting complex subunit 7. | DNA replication and sister chromatid cohesion 1. | 0.754 |
| ANAPC7 | DYRK2 | ENSFCAP00000020067 | ENSFCAP00000010312 | Anaphase promoting complex subunit 7. | Dual specificity tyrosine phosphorylation regulated kinase 2. | 0.761 |
| ANAPC7 | HUS1 | ENSFCAP00000020067 | ENSFCAP00000047979 | Anaphase promoting complex subunit 7. | Checkpoint protein; Belongs to the HUS1 family. | 0.621 |
| ATM | DDB1 | ENSFCAP00000025928 | ENSFCAP00000024813 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Damage specific DNA binding protein 1. | 0.414 |
| ATM | DYRK2 | ENSFCAP00000025928 | ENSFCAP00000010312 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Dual specificity tyrosine phosphorylation regulated kinase 2. | 0.892 |
| ATM | HUS1 | ENSFCAP00000025928 | ENSFCAP00000047979 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Checkpoint protein; Belongs to the HUS1 family. | 0.783 |
| ATM | MDM2 | ENSFCAP00000025928 | ENSFCAP00000025067 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] | 0.964 |
| ATM | TP53 | ENSFCAP00000025928 | ENSFCAP00000045749 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.991 |
| CCDC71 | DYRK2 | ENSFCAP00000059293 | ENSFCAP00000010312 | Coiled-coil domain containing 71. | Dual specificity tyrosine phosphorylation regulated kinase 2. | 0.455 |
| DCAF7 | DDB1 | ENSFCAP00000024234 | ENSFCAP00000024813 | DDB1 and CUL4 associated factor 7. | Damage specific DNA binding protein 1. | 0.917 |
| DCAF7 | DYRK2 | ENSFCAP00000024234 | ENSFCAP00000010312 | DDB1 and CUL4 associated factor 7. | Dual specificity tyrosine phosphorylation regulated kinase 2. | 0.652 |
| DDB1 | ATM | ENSFCAP00000024813 | ENSFCAP00000025928 | Damage specific DNA binding protein 1. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.414 |
| DDB1 | DCAF7 | ENSFCAP00000024813 | ENSFCAP00000024234 | Damage specific DNA binding protein 1. | DDB1 and CUL4 associated factor 7. | 0.917 |
| DDB1 | DYRK2 | ENSFCAP00000024813 | ENSFCAP00000010312 | Damage specific DNA binding protein 1. | Dual specificity tyrosine phosphorylation regulated kinase 2. | 0.462 |
| DDB1 | MDM2 | ENSFCAP00000024813 | ENSFCAP00000025067 | Damage specific DNA binding protein 1. | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] | 0.462 |
| DDB1 | TP53 | ENSFCAP00000024813 | ENSFCAP00000045749 | Damage specific DNA binding protein 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.402 |
| DSCC1 | ANAPC7 | ENSFCAP00000010167 | ENSFCAP00000020067 | DNA replication and sister chromatid cohesion 1. | Anaphase promoting complex subunit 7. | 0.754 |
| DSCC1 | DYRK2 | ENSFCAP00000010167 | ENSFCAP00000010312 | DNA replication and sister chromatid cohesion 1. | Dual specificity tyrosine phosphorylation regulated kinase 2. | 0.659 |
| DSCC1 | HUS1 | ENSFCAP00000010167 | ENSFCAP00000047979 | DNA replication and sister chromatid cohesion 1. | Checkpoint protein; Belongs to the HUS1 family. | 0.564 |
| DYRK2 | ANAPC7 | ENSFCAP00000010312 | ENSFCAP00000020067 | Dual specificity tyrosine phosphorylation regulated kinase 2. | Anaphase promoting complex subunit 7. | 0.761 |
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