Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FRAS1Fraser extracellular matrix complex subunit 1. (4011 aa)    
Predicted Functional Partners:
FREM1
FRAS1 related extracellular matrix 1.
   
0.934
FREM2
FRAS1 related extracellular matrix 2.
   
 0.931
ITGA8
Integrin subunit alpha 8; Belongs to the integrin alpha chain family.
   
 
 0.916
ITGB1
Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...]
    
  0.896
NPNT
Nephronectin.
    
 0.880
PTPRK
Protein tyrosine phosphatase receptor type K.
   
 0.852
EDN3
Uncharacterized protein.
      
 0.838
FREM3
FRAS1 related extracellular matrix 3.
   
 0.823
ITGA2B
Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.
   
 
 0.749
ZNF335
Zinc finger protein 335.
    
 0.600
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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