Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ANGPTL3Angiopoietin like 3. (460 aa)    
Predicted Functional Partners:
ANGPTL8
Angiopoietin like 8.
    
 0.984
LPL
Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity).
    
 0.959
ANGPTL4
Angiopoietin like 4.
     
 0.902
GPIHBP1
Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1.
   
 
 0.821
APOA5
Apolipoprotein A5.
   
 0.761
APOB
Apolipoprotein B.
   
  
 0.714
TEK
TEK receptor tyrosine kinase.
   
 0.634
APOC3
Apolipoprotein C3.
   
  
 0.609
TIE1
Tyrosine kinase with immunoglobulin like and EGF like domains 1.
   
 0.589
SERPINC1
Serpin family C member 1; Belongs to the serpin family.
   
 0.549
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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