STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EIF2AEukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (593 aa)    
Predicted Functional Partners:
EIF3B
Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family.
   
 
0.947
EIF2S3
Tr-type G domain-containing protein.
   
 0.722
EIF2S1
Eukaryotic translation initiation factor 2 subunit alpha.
   
 0.664
ENSFCAP00000037913
Uncharacterized protein.
    
  0.660
XRN1
5'-3' exoribonuclease 1.
    
 
 0.629
RPS23
Uncharacterized protein.
    
 0.628
M3XF34_FELCA
Uncharacterized protein; Belongs to the universal ribosomal protein uS12 family.
    
 0.628
DELE1
DAP3 binding cell death enhancer 1.
      
 0.616
ENSFCAP00000036918
Ribosomal_S13_N domain-containing protein.
   
  0.604
ENSFCAP00000037165
Ribosomal_S13_N domain-containing protein.
   
  0.604
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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