STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAPPAPappalysin 1. (1629 aa)    
Predicted Functional Partners:
IGFBP5
Insulin like growth factor binding protein 5.
    
 0.846
STC2
Stanniocalcin 2.
    
 
 0.755
PRG3
Proteoglycan 3, pro eosinophil major basic protein 2.
    
 0.669
ENSFCAP00000053888
Uncharacterized protein.
    
 0.669
TSHR
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
    
 
 0.613
IGF1
Insulin like growth factor 1.
     
 0.612
IGF2
Insulin like growth factor 2.
   
 0.585
IGFBP4
Insulin like growth factor binding protein 4.
   
 
 0.530
APMAP
Adipocyte plasma membrane associated protein.
      
 0.504
ENOX2
Ecto-NOX disulfide-thiol exchanger 2.
      
 0.497
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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