NLRP14 protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NLRP14

NLR family pyrin domain containing 14. (1095 aa)

Predicted Functional Partners:

NLRC4

0.685

PADI6

0.627

CASP4

0.550

SCAF11

0.543

OOEP

0.520

RNASE1

0.502

PYCARD

0.482

ENSFCAP00000057050

0.481

RIPK2

0.473

M3XAD3_FELCA

0.466

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP4	ENSFCAP00000057050	ENSFCAP00000005500	ENSFCAP00000057050	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Gasdermin domain-containing protein.	0.522
CASP4	NLRC4	ENSFCAP00000005500	ENSFCAP00000005570	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NLR family CARD domain containing 4.	0.941
CASP4	NLRP14	ENSFCAP00000005500	ENSFCAP00000010670	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	NLR family pyrin domain containing 14.	0.550
CASP4	PYCARD	ENSFCAP00000005500	ENSFCAP00000051017	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	PYD and CARD domain containing.	0.997
ENSFCAP00000057050	CASP4	ENSFCAP00000057050	ENSFCAP00000005500	Gasdermin domain-containing protein.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.522
ENSFCAP00000057050	NLRP14	ENSFCAP00000057050	ENSFCAP00000010670	Gasdermin domain-containing protein.	NLR family pyrin domain containing 14.	0.481
ENSFCAP00000057050	PYCARD	ENSFCAP00000057050	ENSFCAP00000051017	Gasdermin domain-containing protein.	PYD and CARD domain containing.	0.542
ENSFCAP00000057050	SCAF11	ENSFCAP00000057050	ENSFCAP00000028387	Gasdermin domain-containing protein.	SR-related CTD associated factor 11.	0.703
M3XAD3_FELCA	NLRP14	ENSFCAP00000023586	ENSFCAP00000010670	Uncharacterized protein.	NLR family pyrin domain containing 14.	0.466
NLRC4	CASP4	ENSFCAP00000005570	ENSFCAP00000005500	NLR family CARD domain containing 4.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.941
NLRC4	NLRP14	ENSFCAP00000005570	ENSFCAP00000010670	NLR family CARD domain containing 4.	NLR family pyrin domain containing 14.	0.685
NLRC4	PYCARD	ENSFCAP00000005570	ENSFCAP00000051017	NLR family CARD domain containing 4.	PYD and CARD domain containing.	0.985
NLRP14	CASP4	ENSFCAP00000010670	ENSFCAP00000005500	NLR family pyrin domain containing 14.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.550
NLRP14	ENSFCAP00000057050	ENSFCAP00000010670	ENSFCAP00000057050	NLR family pyrin domain containing 14.	Gasdermin domain-containing protein.	0.481
NLRP14	M3XAD3_FELCA	ENSFCAP00000010670	ENSFCAP00000023586	NLR family pyrin domain containing 14.	Uncharacterized protein.	0.466
NLRP14	NLRC4	ENSFCAP00000010670	ENSFCAP00000005570	NLR family pyrin domain containing 14.	NLR family CARD domain containing 4.	0.685
NLRP14	OOEP	ENSFCAP00000010670	ENSFCAP00000006294	NLR family pyrin domain containing 14.	Oocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the KHDC1 family.	0.520
NLRP14	PADI6	ENSFCAP00000010670	ENSFCAP00000009458	NLR family pyrin domain containing 14.	Peptidyl arginine deiminase 6.	0.627
NLRP14	PYCARD	ENSFCAP00000010670	ENSFCAP00000051017	NLR family pyrin domain containing 14.	PYD and CARD domain containing.	0.482
NLRP14	RIPK2	ENSFCAP00000010670	ENSFCAP00000016295	NLR family pyrin domain containing 14.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.473