IL10RA protein (Felis catus) - STRING interaction network

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Predicted Interactions

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Score

IL10RA

Interleukin 10 receptor subunit alpha. (578 aa)

Predicted Functional Partners:

JAK1

0.999

IL10

0.996

IL10RB

0.992

TYK2

0.990

CTSK

0.912

JAK3

0.892

JAK2

0.892

STAT3

0.798

IL22

0.798

IL24

0.782

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTSK	IL10RA	ENSFCAP00000052134	ENSFCAP00000010918	Cathepsin S; Belongs to the peptidase C1 family.	Interleukin 10 receptor subunit alpha.	0.912
CTSK	IL10RB	ENSFCAP00000052134	ENSFCAP00000060678	Cathepsin S; Belongs to the peptidase C1 family.	Interleukin 10 receptor subunit beta.	0.907
IL10	IL10RA	ENSFCAP00000012535	ENSFCAP00000010918	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit alpha.	0.996
IL10	IL10RB	ENSFCAP00000012535	ENSFCAP00000060678	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit beta.	0.993
IL10	IL22	ENSFCAP00000012535	ENSFCAP00000014399	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22.	0.802
IL10	IL24	ENSFCAP00000012535	ENSFCAP00000012823	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 24.	0.542
IL10	JAK1	ENSFCAP00000012535	ENSFCAP00000001806	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.716
IL10	JAK2	ENSFCAP00000012535	ENSFCAP00000049673	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.675
IL10	JAK3	ENSFCAP00000012535	ENSFCAP00000006963	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.431
IL10	STAT3	ENSFCAP00000012535	ENSFCAP00000001991	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Signal transducer and activator of transcription.	0.825
IL10	TYK2	ENSFCAP00000012535	ENSFCAP00000008752	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.513
IL10RA	CTSK	ENSFCAP00000010918	ENSFCAP00000052134	Interleukin 10 receptor subunit alpha.	Cathepsin S; Belongs to the peptidase C1 family.	0.912
IL10RA	IL10	ENSFCAP00000010918	ENSFCAP00000012535	Interleukin 10 receptor subunit alpha.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.996
IL10RA	IL10RB	ENSFCAP00000010918	ENSFCAP00000060678	Interleukin 10 receptor subunit alpha.	Interleukin 10 receptor subunit beta.	0.992
IL10RA	IL22	ENSFCAP00000010918	ENSFCAP00000014399	Interleukin 10 receptor subunit alpha.	Interleukin 22.	0.798
IL10RA	IL24	ENSFCAP00000010918	ENSFCAP00000012823	Interleukin 10 receptor subunit alpha.	Interleukin 24.	0.782
IL10RA	JAK1	ENSFCAP00000010918	ENSFCAP00000001806	Interleukin 10 receptor subunit alpha.	Tyrosine-protein kinase.	0.999
IL10RA	JAK2	ENSFCAP00000010918	ENSFCAP00000049673	Interleukin 10 receptor subunit alpha.	Tyrosine-protein kinase.	0.892
IL10RA	JAK3	ENSFCAP00000010918	ENSFCAP00000006963	Interleukin 10 receptor subunit alpha.	Tyrosine-protein kinase.	0.892
IL10RA	STAT3	ENSFCAP00000010918	ENSFCAP00000001991	Interleukin 10 receptor subunit alpha.	Signal transducer and activator of transcription.	0.798