Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)    
Predicted Functional Partners:
LRP6
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
    
 0.961
FZD4
Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.
  
 
 0.948
DKK1
Dickkopf WNT signaling pathway inhibitor 1.
    
 0.931
LRP5
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
    
 0.930
FZD3
Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.929
FZD6
Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.928
PORCN
Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family.
    
 0.927
FZD10
Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.908
SFRP2
Secreted frizzled related protein 2.
    
 0.895
FZD2
Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.887
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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