MAP4K2 protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

MAP4K2

Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa)

Predicted Functional Partners:

TRAF2

0.909

MAP3K1

0.817

TRAF1

0.814

MAP3K11

0.639

LATS1

0.608

MAPK8IP1

0.566

MAPK8IP2

0.562

PIK3C2G

0.554

CRKL

0.500

PHF12

0.480

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRKL	MAP3K1	ENSFCAP00000005579	ENSFCAP00000013081	CRK like proto-oncogene, adaptor protein.	Mitogen-activated protein kinase kinase kinase 1.	0.894
CRKL	MAP4K2	ENSFCAP00000005579	ENSFCAP00000011352	CRK like proto-oncogene, adaptor protein.	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	0.500
LATS1	MAP4K2	ENSFCAP00000022176	ENSFCAP00000011352	Large tumor suppressor kinase 1.	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	0.608
MAP3K1	CRKL	ENSFCAP00000013081	ENSFCAP00000005579	Mitogen-activated protein kinase kinase kinase 1.	CRK like proto-oncogene, adaptor protein.	0.894
MAP3K1	MAP4K2	ENSFCAP00000013081	ENSFCAP00000011352	Mitogen-activated protein kinase kinase kinase 1.	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	0.817
MAP3K1	TRAF1	ENSFCAP00000013081	ENSFCAP00000051800	Mitogen-activated protein kinase kinase kinase 1.	TNF receptor-associated factor.	0.947
MAP3K1	TRAF2	ENSFCAP00000013081	ENSFCAP00000000359	Mitogen-activated protein kinase kinase kinase 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.974
MAP3K11	MAP4K2	ENSFCAP00000018256	ENSFCAP00000011352	Mitogen-activated protein kinase kinase kinase.	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	0.639
MAP3K11	MAPK8IP1	ENSFCAP00000018256	ENSFCAP00000049975	Mitogen-activated protein kinase kinase kinase.	Mitogen-activated protein kinase 8 interacting protein 1.	0.970
MAP3K11	MAPK8IP2	ENSFCAP00000018256	ENSFCAP00000060711	Mitogen-activated protein kinase kinase kinase.	Mitogen-activated protein kinase 8 interacting protein 2.	0.945
MAP4K2	CRKL	ENSFCAP00000011352	ENSFCAP00000005579	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	CRK like proto-oncogene, adaptor protein.	0.500
MAP4K2	LATS1	ENSFCAP00000011352	ENSFCAP00000022176	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Large tumor suppressor kinase 1.	0.608
MAP4K2	MAP3K1	ENSFCAP00000011352	ENSFCAP00000013081	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Mitogen-activated protein kinase kinase kinase 1.	0.817
MAP4K2	MAP3K11	ENSFCAP00000011352	ENSFCAP00000018256	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Mitogen-activated protein kinase kinase kinase.	0.639
MAP4K2	MAPK8IP1	ENSFCAP00000011352	ENSFCAP00000049975	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Mitogen-activated protein kinase 8 interacting protein 1.	0.566
MAP4K2	MAPK8IP2	ENSFCAP00000011352	ENSFCAP00000060711	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Mitogen-activated protein kinase 8 interacting protein 2.	0.562
MAP4K2	PHF12	ENSFCAP00000011352	ENSFCAP00000006533	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	PHD finger protein 12.	0.480
MAP4K2	PIK3C2G	ENSFCAP00000011352	ENSFCAP00000034635	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family.	0.554
MAP4K2	TRAF1	ENSFCAP00000011352	ENSFCAP00000051800	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	TNF receptor-associated factor.	0.814
MAP4K2	TRAF2	ENSFCAP00000011352	ENSFCAP00000000359	Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.909

page 1 of 2

Server load: low (38%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About