Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPRED1Sprouty related EVH1 domain containing 1. (443 aa)    
Predicted Functional Partners:
NF1
Neurofibromin 1.
    
 0.962
SPRED2
Sprouty related EVH1 domain containing 2.
   
 
  0.854
FGFRL1
Fibroblast growth factor receptor like 1.
     
 0.805
OFD1
OFD1 centriole and centriolar satellite protein.
    
 
 0.767
HEPACAM
Hepatic and glial cell adhesion molecule.
      
 0.761
RIN2
Ras and Rab interactor 2.
      
 0.761
EZH2
Enhancer of zeste 2 polycomb repressive complex 2 subunit.
      
 0.724
PIK3R2
Phosphoinositide-3-kinase regulatory subunit 2.
      
 0.684
CENPJ
Centromere protein J.
      
 0.674
MCPH1
Uncharacterized protein.
      
 0.643
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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