HGFAC protein (Felis catus) - STRING interaction network

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Score

HGFAC

HGF activator. (650 aa)

Predicted Functional Partners:

HGF

0.906

WDR90

0.867

MET

0.856

LOC101085453

0.845

PTK7

0.780

SPINT4

0.766

LOC101085707

0.751

SPINT2

0.748

RNASEL

0.702

RIPK4

0.695

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HGF	HGFAC	ENSFCAP00000033735	ENSFCAP00000011727	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity).	HGF activator.	0.906
HGF	MET	ENSFCAP00000033735	ENSFCAP00000060432	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity).	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.999
HGF	SPINT2	ENSFCAP00000033735	ENSFCAP00000022734	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity).	Serine peptidase inhibitor, Kunitz type 2.	0.905
HGFAC	HGF	ENSFCAP00000011727	ENSFCAP00000033735	HGF activator.	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity).	0.906
HGFAC	LOC101085453	ENSFCAP00000011727	ENSFCAP00000015868	HGF activator.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.845
HGFAC	LOC101085707	ENSFCAP00000011727	ENSFCAP00000011020	HGF activator.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.751
HGFAC	MET	ENSFCAP00000011727	ENSFCAP00000060432	HGF activator.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.856
HGFAC	PTK7	ENSFCAP00000011727	ENSFCAP00000009013	HGF activator.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.780
HGFAC	RIPK4	ENSFCAP00000011727	ENSFCAP00000038515	HGF activator.	Receptor interacting serine/threonine kinase 4.	0.695
HGFAC	RNASEL	ENSFCAP00000011727	ENSFCAP00000025413	HGF activator.	Ribonuclease L.	0.702
HGFAC	SPINT2	ENSFCAP00000011727	ENSFCAP00000022734	HGF activator.	Serine peptidase inhibitor, Kunitz type 2.	0.748
HGFAC	SPINT4	ENSFCAP00000011727	ENSFCAP00000058429	HGF activator.	Serine peptidase inhibitor, Kunitz type 4.	0.766
HGFAC	WDR90	ENSFCAP00000011727	ENSFCAP00000058185	HGF activator.	WD repeat domain 90.	0.867
LOC101085453	HGFAC	ENSFCAP00000015868	ENSFCAP00000011727	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	HGF activator.	0.845
LOC101085453	MET	ENSFCAP00000015868	ENSFCAP00000060432	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.557
LOC101085453	SPINT2	ENSFCAP00000015868	ENSFCAP00000022734	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Serine peptidase inhibitor, Kunitz type 2.	0.621
LOC101085707	HGFAC	ENSFCAP00000011020	ENSFCAP00000011727	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	HGF activator.	0.751
LOC101085707	MET	ENSFCAP00000011020	ENSFCAP00000060432	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.557
LOC101085707	SPINT2	ENSFCAP00000011020	ENSFCAP00000022734	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	Serine peptidase inhibitor, Kunitz type 2.	0.621
MET	HGF	ENSFCAP00000060432	ENSFCAP00000033735	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity).	0.999