DCC protein (Felis catus) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

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[Homology]

Score

DCC

DCC netrin 1 receptor. (1446 aa)

Predicted Functional Partners:

NTN1

0.996

PTK2

0.994

APPL1

0.992

CASP3

0.976

CASP9

0.965

SRC

0.938

APPL2

0.931

UNC5A

0.916

UNC5C

0.914

PLCG1

0.914

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL1	APPL2	ENSFCAP00000033650	ENSFCAP00000001356	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.989
APPL1	CASP3	ENSFCAP00000033650	ENSFCAP00000031946	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.960
APPL1	CASP9	ENSFCAP00000033650	ENSFCAP00000018153	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Caspase 9; Belongs to the peptidase C14A family.	0.920
APPL1	DCC	ENSFCAP00000033650	ENSFCAP00000012015	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	DCC netrin 1 receptor.	0.992
APPL2	APPL1	ENSFCAP00000001356	ENSFCAP00000033650	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.989
APPL2	CASP3	ENSFCAP00000001356	ENSFCAP00000031946	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.618
APPL2	CASP9	ENSFCAP00000001356	ENSFCAP00000018153	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Caspase 9; Belongs to the peptidase C14A family.	0.618
APPL2	DCC	ENSFCAP00000001356	ENSFCAP00000012015	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	DCC netrin 1 receptor.	0.931
CASP3	APPL1	ENSFCAP00000031946	ENSFCAP00000033650	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.960
CASP3	APPL2	ENSFCAP00000031946	ENSFCAP00000001356	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.618
CASP3	CASP9	ENSFCAP00000031946	ENSFCAP00000018153	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.986
CASP3	DCC	ENSFCAP00000031946	ENSFCAP00000012015	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	DCC netrin 1 receptor.	0.976
CASP3	PTK2	ENSFCAP00000031946	ENSFCAP00000033797	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.636
CASP3	SRC	ENSFCAP00000031946	ENSFCAP00000041142	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.659
CASP3	UNC5A	ENSFCAP00000031946	ENSFCAP00000028144	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Unc-5 netrin receptor A.	0.402
CASP9	APPL1	ENSFCAP00000018153	ENSFCAP00000033650	Caspase 9; Belongs to the peptidase C14A family.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.920
CASP9	APPL2	ENSFCAP00000018153	ENSFCAP00000001356	Caspase 9; Belongs to the peptidase C14A family.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.618
CASP9	CASP3	ENSFCAP00000018153	ENSFCAP00000031946	Caspase 9; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.986
CASP9	DCC	ENSFCAP00000018153	ENSFCAP00000012015	Caspase 9; Belongs to the peptidase C14A family.	DCC netrin 1 receptor.	0.965
CASP9	SRC	ENSFCAP00000018153	ENSFCAP00000041142	Caspase 9; Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.490