Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
RETRet proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1138 aa)    
Predicted Functional Partners:
GFRA1
GDNF family receptor alpha 1.
    
 0.996
GFRA2
GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
    
 0.991
NRTN
Neurturin.
    
 0.987
GRB2
Growth factor receptor bound protein 2.
   
 0.979
GFRA3
GDNF family receptor alpha 3.
    
 0.972
GDNF
Glial cell derived neurotrophic factor.
    
 0.968
GFRA4
GDNF family receptor alpha 4.
     
 0.965
PLCG1
Phosphoinositide phospholipase C.
    
 0.963
PSPN
Persephin.
     
 0.961
NCOA4
Nuclear receptor coactivator 4.
     
 0.958
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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