STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RETRet proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1138 aa)    
Predicted Functional Partners:
GFRA1
GDNF family receptor alpha 1.
    
 0.995
GFRA2
GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
    
 0.990
GFRA3
GDNF family receptor alpha 3.
    
 0.976
NRTN
Neurturin.
    
 0.972
GDNF
Glial cell derived neurotrophic factor.
    
 0.966
CCDC6
Coiled-coil domain containing 6.
     
 0.950
GFRA4
GDNF family receptor alpha 4.
     
 0.949
NCOA4
Nuclear receptor coactivator 4.
    
 0.937
DOK1
Docking protein 1.
    
  0.916
PSPN
Persephin.
     
 0.850
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.