Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PGK1Phosphoglycerate kinase. (454 aa)    
Predicted Functional Partners:
TPI1
Triosephosphate isomerase.
 
 0.995
GAPDHS
Glyceraldehyde-3-phosphate dehydrogenase.
  
 0.932
BPGM
Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
   
 0.925
PGAM1
Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
   
 0.923
PGAM2
Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
   
 0.922
GPI
Glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 0.916
GAPDH
Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]
  
 0.880
ENO1
Enolase 1.
  
 0.857
M3X4Q0_FELCA
Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  
 0.840
ENSFCAP00000053301
Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  
 0.840
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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